Publications of the Bf3R

The scientists of the German Center for the Protection of Laboratory Animals (Bf3R) regularly publish the results of their scientific work in form of peer-reviewed articles in journals or on document servers for preprints, in form of conference publications, as book chapters and patents.

Here you will find a list of Bf3R publications since 2015, sorted by year of publication:

2024:

Drude, N., Nagel-Riedasch, S., Rosshart, S. P., Diefenbach, A., Diederich, K., Duerr, C. U., Harms, C., Heppner, F., Kolesnichenko, M., Lewejohann, L., Mall, M. A., Müller, D., Opitz, B., Rosshart, S. P., Schönfelder, G., Tölch, U., Willimsky, G. and Jordan, S. (2024). "A facility for laboratory mice with a natural microbiome at Charité – Universitätsmedizin Berlin". Lab animal : information, ideas, methods and materials for the animal research professional
https://www.nature.com/articles/s41684-024-01474-4

Atter, A., Ofori, H., Akonor, P. T., Andoh-Odoom, A., Ampah, J., Owusu, M., Peget, F., Overå, R., Kolding, J., Pucher, J. and Kjellevold, M. (2024). Enriched local convenience foods with two different small pelagic fish species increases the nutritional value without compromising taste. International Journal of Gastronomy and Food Science 37(-):100956.
http://dx.doi.org/https://doi.org/10.1016/j.ijgfs.2024.100956

Becker, P. C., Güth-Steffens, M., Lazarow, K., Sonntag, N., Braun, D., Masfaka, I., Renko, K., Schomburg, L., Köhrle, J., von Kries, J. P., Schweizer, U., Krause, G., Protze, P. (2024). Identification of Human TRIAC Transmembrane Transporters. Thyroid 34(7):920-930
https://doi.org/10.1089/thy.2023.0592

Bredow, C., Thery, F., Wirth, E. K., Kespohl, M., Kleinau, G., Kelm, N., Gimber, N., Schmoranzer, J., Voss, M., Klingel, K., Spranger, J., Renko, K., Ralser, M., Mülleder, M., Heuser, A., Knobeloch, K.-P., Scheerer, P., Kirwan, J., Brüning, U., Berndt, N., Impens, F. and Beling, A. (2024). ISG15 blocks cardiac glycolysis and ensures sufficient mitochondrial energy production during Coxsackievirus B3 infection. Cardiovascular Research.
http://dx.doi.org/10.1093/cvr/cvae026

Butzke, D., Bert, B., Gulich, K., Schönfelder, G. and Neves, M. (preprint). SMAFIRA: a literature-based web tool to assist researchers with retrieval of 3R-relevant information. Laboratory Animals.
http://dx.doi.org/10.1177/00236772241237608

Canbolat, P., Wilzopolski, J., Kaessmeyer, S., Filor, V., Vidak, J., Rüger, M., Mägert, H.-J., Forssmann, W.-G. and Bäumer, W. (2024). LEKTI domain 6 displays anti-inflammatory action in vitro and in a murine atopic dermatitis model. Journal of Dermatological Science 115(1):13-20.
http://dx.doi.org/10.1016/j.jdermsci.2024.03.004

Diederich, K., Steinfath, M., Bannach-Brown, A., Bert, B., Butzke, D., Wildner, P. L., Wurm, M., Schadock, I. and Heinl, C. (2024). Protocol for the systematic review of age and sex in preclinical models of age-correlated diseases. F1000Research 13(-)
https://doi.org/10.12688/f1000research.153466.1

Gerhardt, P., Begall, S., Frädrich, C., Renko, K., Heinrich, A., Köhrle, J. and Henning, Y. (2024). Low thyroxine serves as an upstream regulator of ecophysiological adaptations in Ansell’s mole-rats. Frontiers in Endocrinology.
https://doi.org/10.3389/fendo.2024.1329083

Hohlbaum, K., Andresen, N., Mieske, P., Kahnau, P., Lang, B., Diederich, K., Palme, R., Mundhenk, L., Sprekeler, H., Hellwich, O., Thöne-Reineke, C. and Lewejohann, L. (2024). Lockbox enrichment facilitates manipulative and cognitive activities for mice [version 2; peer review: 2 approved]. Open Research Europe 4(-):108
https://doi.org/10.12688/openreseurope.17624.2

Hohlbaum, K., Merle, R., Warnke, R., Nagel-Riedasch, S., Thöne-Reineke, C. and Ullmann, K. (online first 2023). The implementation of tunnel handling in a mouse breeding facility revealed strain-specific behavioural responses. Laboratory Animals 0(0):1-13
https://doi.org/10.1177/00236772231215077

Jo, S., Park, S. B., Kim, H., Im, I., Noh, H., Kim, E.-M., Kim, K. Y., Oelgeschlaeger, M., Kim, J.-H. and Park, H.-J. (2024). hiPSC-derived macrophages improve drug sensitivity and selectivity in a macrophage-incorporating organoid culture model. Biofabrication.
http://dx.doi.org/10.1088/1758-5090/ad4c0a

Kadic, A., Oles, P., Fischer, B. C., Reetz, A. E., Sylla, B.S., Feiertag, K., Ritz, V., Heise, T., Marx-Stölting, P., Tralau, T., Renko, K. and Solano, M. d. L. M. (2024). In vitro and in vivo investigation of a thyroid hormone system-specific interaction with triazoles. Scientific Reports.
https://doi.org/10.1038/s41598-024-55019-3

Kim, H., Kim, S. K., Oelgeschläger, M. and Park, H.-J. (2024). Prediction of Acute Hepatotoxicity With Human Pluripotent Stem Cell-Derived Hepatic Organoids. Current Protocols 4(4):e1015.
http://dx.doi.org/10.1002/cpz1.1015

Kitsara, M., Smajlhodži?-Deljo, M., Gurbeta Pokvic, L., Bert, B., Bubalo, N., Erden, S., Franco, N. H., Chirico, G., Gómez Raja, J., Gonzalez-Uarquin, F., Lang, A., Linklater, N., Mojsova, S., Olsson, I. A. S., Sandvig, I., Schaffert, A., Schmit, M., Schober, S., Sevastre, B., Wilflingseder, D., Ahluwalia, A. and Neuhaus, W. (2024). Introduction of the COST Action IMPROVE on Improving the Quality of Biomedical Science with 3Rs Concepts ATLA (Alternatives to Laboratory Animals) 52(6):326-333
https://doi.org/10.1177/02611929241286024

Lauwereyns, J., Bajramovic, J., Bert, B., Camenzind, S., De Kock, J., Elezovi?, A., Erden, S., Gonzalez-Uarquin, F., Ulman, Y. I., Hoffmann, O. I., Kitsara, M., Kostomitsopoulos, N., Neuhaus, W., Petit-Demouliere, B., Pollo, S., Riso, B., Schober, S., Sotiropoulos, A., Thomas, A., Vitale, A., Wilflingseder, D. and Ahluwalia, A. (2024). "Toward a common interpretation of the 3Rs principles in animal research". Lab animal 2024
https://doi.org/10.1038/s41684-024-01476-2

Li, Y., Deng, D., Höfer, C. T., Kim, J., Heo, W. D., Xu, Q., Liu, X. and Zi, Z. (2024). Liebig’s law of the minimum in the TGF-β pathway. Nature Structural & Molecular Biology.
https://doi.org/10.1101/2023.07.10.548398

Neves, M. (preprint). Detection of fields of applications in biomedical abstracts with the support of argumentation elements. arXiv.
http://dx.doi.org/10.48550/arXiv.2404.06121

Odje, F., Meijer, D., Von Coburg, E., Van der Hooft, J. J. J., Dunst, S., Medema, M. H. and Volkamer, A. (2024). Unleashing the potential of cell painting assays for compound activities and hazards prediction. Frontiers in Toxicology 6(-):1401036
https://doi.org/10.3389/ftox.2024.1401036

Ohnesorge, N., Wilzopolski, J., Steinfath, M., Lewejohann, L., Banneke, S., Heinl, C. (Preprint) Assessment of the effect of tricaine (MS-222)-induced anesthesia on brain-wide neuronal activity of zebrafish (Danio rerio) larvae. Front. Neurosci., 24 September 2024, Sec. Neuropharmacology, Volume 18 - 2024
https://doi.org/10.3389/fnins.2024.1456322

Pederson, C., Vogliano, C., Sadoff, C., D’Cruz, G., Kennedy, G., White, G., Alleway, H., Kim, J. K., Pucher, J., Koome, K., Geagan, K., Chang, K., Mbuya, M., Sumaila, R., Thilsted, S., Palmer, S., Oenema, S., Zimpita, T., Agostini, V. and Battista, W. (2024). Regenerative Aquatic Foods Roadmap.
https://www.aquaculturescience.org/content/dam/tnc/nature/en/documents/RegenerativeAquaticFoodsRoadmap.pdf

Pont, C., Sampietro, A., Pérez-Areales, F. J., Cristiano, N., Albalat, A., Pérez, B., Bartolini, M., De Simone, A., Andrisano, V., Barenys, M., Teixidó, E., Sabaté, R., Loza, M. I., Brea, J. and Muñoz-Torrero, D. (2024). Stepwise Structural Simplification of the Dihydroxyanthraquinone Moiety of a Multitarget Rhein-Based Anti-Alzheimer Lead to Improve Drug Metabolism and Pharmacokinetic Properties. Pharmaceutics 16(8):982
https://doi.org/10.3390/pharmaceutics16080982

Schlegel, L., Kleine, A. S., Doherr, M. G. and Fischer-Tenhagen, C. (2024). How to see stress in chickens: On the way to a Stressed Chicken Scale. Poultry Science 103(8).
http://dx.doi.org/10.1016/j.psj.2024.103875

Wagenaars, F., Cenijn, P., Scholze, M., Frädrich, C., Renko, K., Köhrle, J. and Hamers, T. (Online ahead of print). Screening for endocrine disrupting chemicals inhibiting monocarboxylate 8 (MCT8) facilitated thyroid hormone transport using a modified nonradioactive assay. Toxicology in vitro 96.
http://dx.doi.org/10.1016/j.tiv.2023.105770

Wilhelmi, P., Haake, V., Zickgraf, F. M., Giri, V., Ternes, P., Driemert, P., Nöth, J., Scholz, S., Barenys Espadaler, M., Flick, B., Birk, B., Kamp, H., Landsiedel, R. and Funk-Weyer, D. (2024). Molecular signatures of angiogenesis inhibitors: a single-embryo untargeted metabolomics approach in zebrafish. Archives of Toxicology 98(-):943-956
https://doi.org/10.1007/s00204-023-03655-5

Vogliano, C., Kennedy, G., Alleway, H., Sadoff, C., D’Cruz, G., White, G., Kim, J. K., Pucher, J., Koome, K., Geagan, K., Chang, K., Mbuya, M., Thilsted, S., Palmer, S., Sumaila, U. R. and Battista, W. (2024). Regenerative aquatic foods can be a win-win for human and planetary health. Nature Food 5(-):718–719
https://doi.org/10.1038/s43016-024-01043-5

2023:

SCHEER (Scientific Committee on Health, Environmental and Emerging Risks), Opinion on the Revision of Annexes III and IV of Directive 2010/63/EU on the protection of animals used for scientific purposes regarding accommodation parameters and methods of killing for zebrafish, and accommodation parameters for Passerine birds, adopted on 25 September 2023
https://health.ec.europa.eu/publications/scheer-revision-annexes-iii-and-iv-directive-201063eu-protection-animals-used-scientific-purposes_en

Audebert, M., Assmann, A.-S., Azqueta, A., Babica, P., Benfenati, E., Bortoli, S., Bouwman, P., Braeuning, A., Burgdorf, T., Coumoul, X., Debizet, K., Dusinska, M., Ertych, N., Fahrer, J., Fetz, V., Le Hegarat, L., Lopez de Cerain, A., Heusinkveld, H. J., Hogeveen, K., Jacobs, M. N., Luijten, M., Raitano, G., Recoules, C., Runden-Pran, E., Saleh, M., Sovadinova, I., Stampar, M., Thibol, L., Tomkiewicz, C., Vettorazzi, A., Van de Water, B., El Yamani, N., Zegura, B. and Oelgeschläger, M. (2023). New approach methodologies to facilitate and improve the hazard assessment of non-genotoxic carcinogens-a PARC project. Frontiers in Toxicology 5:1220998. http://dx.doi.org/10.3389/ftox.2023.1220998

Brandwein, C., Leenaars, C. H. C., Becker, L., Pfeiffer, N., Iorgu, A.-M., Hahn, M., Vairani, G. A., Lewejohann, L., Bleich, A., Mallien, A. S. and Gass, P. (2023). A systematic mapping review of the evolution of the rat Forced Swim Test: Protocols and outcome parameters. Pharmacological Research 196:106917. http://dx.doi.org/10.1016/j.phrs.2023.106917

Dolokov, A., Andersen, N., Hohlbaum, K., Thöne-Reineke, C., Lewejohann, L., Hellwich, O. (2023) Upper bound tracker: a multi-animal tracking solution for closed laboratory settings. Scitepress, 4, 945–952. https://dx.doi.org/10.5220/0011609500003417

Engel, A. M., El-Khatib, A. H., Klevenhusen, F., Weiss, M., Aboling, S., Sachse, B., Schäfer, B., Weigel, S., Pieper, R. and Fischer-Tenhagen, C. (2023). Detection of Hypoglycin A and MCPrG Metabolites in the Milk and Urine of Pasture Dairy Cows after Intake of Sycamore Seedlings. Journal of agricultural and food chemistry 71:10751-10760. http://dx.doi.org/https://doi.org/10.1021/acs.jafc.3c01248

Fischer-Tenhagen, C., Bohm, D., Finnah, A., Arlt, S., Schlesinger, S., Borchardt, S., Sutter, F., Tippenhauer, C. M., Heuwieser, W. and Venjakob, P. L. (2023). Residue Concentrations of Cloxacillin in Milk after Intramammary Dry Cow Treatment Considering Dry Period Length. Animals 13(16):2558. http://dx.doi.org/https://doi.org/10.3390/ani13162558

GarridoGamarro, E., Svanevik, C. S., Lundebye, A.-K., Sanden, M., D’Agostino, E., Kjellevold, M., Pincus, L. and Pucher, J. (2023). Challenges in the Implementation of Food Safety and Quality Assurance Systems in Small-Scale Fisheries. Food Quality and Safety, 7, 1-9. http://dx.doi.org/10.1093/fqsafe/fyad007

Gerhardt, P., Begall, S., Frädrich, C., Renko, K., Hildebrandt, T. B., Holtze, S., Heinrich, A., Sahm, A., Meci, X., Köhrle, J., Rijntjes, E. and Henning, Y. (2023). Comparative analysis of thyroid hormone systems in rodents with subterranean lifestyle. Scientific Reports 13, 3122. http://dx.doi.org/10.1038/s41598-023-30179-w

Hackler, J., Demircan, K., Chillon, T. S., Sun, Q., Geisler, N., Schupp, M., Renko, K., Schomburg, L. (2023) High throughput drug screening identifies resveratrol as suppressor of hepatic SELENOP expression. Redox Biology, 2023 Feb; 59: 102592. https://doi.org/10.1016/j.redox.2022.102592

Hobbiesiefken, U., Urmersbach, B., Jaap, A., Diederich, K. and Lewejohann, L. (2023). Rating enrichment items by female group-housed laboratory mice in multiple binary choice tests using an RFID-based tracking system. PLoS One 18 (1), e0278709. http://dx.doi.org/10.1371/journal.pone.0278709

Kahnau, P., Jaap, A., Diederich, K., Gygax, L., Rudeck, J. and Lewejohann, L. (2023). Determining the value of preferred goods based on consumer demand in a home-cage based test for mice. Behavior Research Methods 55 (2), 751-766. http://dx.doi.org/10.3758/s13428-022-01813-8

Kahnau, P., Jaap, A., Urmersbach, B., Diederich, K. and Lewejohann, L. (2022). Development of an IntelliCage-based cognitive bias test for mice. Open Research Europe. http://dx.doi.org/https://doi.org/10.12688/openreseurope.15294.1

Knipper, A.-D., Göhlich, S., Stingl, K., Ghoreishi, N., Fischer-Tenhagen, C., Bandick, N., Tenhagen, B.-A. and Crease, T. (2023). Longitudinal Study for the Detection and Quantification of Campylobacter spp. in Dairy Cows during Milking and in the Dairy Farm Environment. Foods 12(8). http://dx.doi.org/https://doi.org/10.3390/foods12081639

Koch, F., Pieper, R. and Fischer-Tenhagen, C. (2023). Messung der Körpertemperatur beim Schwein: Können Infrarotthermometer eine Alternative sein?. Tierärztliche Praxis: Ausgabe Großtiere / Nutztiere 51(02):84-92. http://dx.doi.org/10.1055/a-2046-5061

Körber, N. (2023) MIA is an open-source standalone deep learning application for microscopic image analysis. Cell Reports Methods, 26 June 2023. https://doi.org/10.1016/j.crmeth.2023.100517

Kühne, B. A., Gutierrez-Vázquez, L., Sánchez Lamelas, E., Guardia-Escote, L., Pla, L., Loreiro, C., VGratacós, E., Barenys, M. and Illa, M. (2023). Lactoferrin/sialic acid prevents adverse effects of intrauterine growth restriction on neurite length: investigations in an in vitro rabbit neurosphere model. Frontiers in Celular Neuroscience 17. http://dx.doi.org/https://doi.org/10.3389/fncel.2023.1116405

Lang, B., Kahnau, P., Hohlbaum , K., Mieske, P., Andresen, N. P., Boon, M. N., Thöne-Reineke, C., Lewejohann, L. and Diederich, K. (2023). Challenges and advanced concepts for the assessment of learning and memory function in mice. Frontiers in Behavioral Neuroscience 17:1230082. http://dx.doi.org/https://doi.org/10.3389/fnbeh.2023.1230082

Mieske, P., Scheinpflug, J., Yorgan, T. A., Brylka, L., Palme, R., Hobbiesiefken, U., Preikschat, J., Lewejohann, L. and Diederich, K. (2023). Effects of more natural housing conditions on the muscular and skeletal characteristics of female C57BL/6J mice. Laboratory Animal Research 39:9. http://dx.doi.org/10.1186/s42826-023-00160-9

Mills, D. J., Simmance, F., Byrd, K., Ahern, M., Cohen, P., D’Agostino, E., Fiorella, K., Garrido-Gamarro., E., Gondwe, E., Hicks, C., Kaunda, E., Kjellevold, M., Kolding, J., Levsen, A., Lundebye, A. K., Marinda, P., McNeil, A., Nagoli, J., Nankwenya, B., Nico, G., O’Meara, L., Pincus, L., Pucher, J., J., R., Roscher, M., Sanden, M., Seow, T. K., Svanevik, C., Teoh, S. J., Thilsted, S., Tilley, A. and Tuazon, M. A. (2023). Contributions of small-scale fisheries to food security and nutrition. Illuminating Hidden Harvests. 145-174. https://www.fao.org/3/cc4576en/cc4576en.pdf

Neves, M., Klippert, A., Knöspel, F., Rudeck, J., Stolz, A., Ban, Z., Becker, M., Diederich, K., Grune, B., Kahnau, P., Ohnesorge, N., Pucher, J., Schönfelder, G., Bert, B. and Butzke, D. (2023). Automatic classification of experimental models in biomedical literature to support searching for alternative methods to animal experiments. Journal of Biomedical Semantics 14(13). http://dx.doi.org/https://doi.org/10.1186/s13326-023-00292-w

Ramhoj, L., Axelstad, M., Baert, Y., Canas-Portilla, A., Chalmel, F., Dahmen, L., de la Vieja, A., Evrard, B., Haigis, A.C., Hamers, T., Heikamp, K., Holbech, H., Iglesias-Hernandez, P., Knapen, D., Marchandise, L., Morthorst, J.E., Nikolov, N.G., Nissen, A.C.V.E., Oelgeschlaeger, M., Renko, K., Rogiers, V., Schüürmann, G., Stinckens, E., Stub, M.H., Torres-Ruiz, M., Van Duursen, M., Vanhaecke, T., Vergauwen, L., Wedebye, E.B., Svingen, T. (2023) New approach methods to improve human health risk assessment of thyroid hormone system disruption–a PARC project. Frontiers Toxicology, 17 May 2023.
https://doi.org/10.3389/ftox.2023.1189303

Romero, N. G., Gutierrez, G., Teixido, E., Li, L., Klose, J., Leung, P. C., Cañigueral, S., Fritsche, E. and Barenys, M. (2023). Developmental neurotoxicity evaluation of three Chinese herbal medicines in zebrafish larvae by means of two behavioral assays: touch-evoked response and light/dark transition. Reproductive Toxicology 121:108469. http://dx.doi.org/https://doi.org/10.1016/j.reprotox.2023.108469

Scheinpflug, J., Höfer, C. T., Schmerbeck, S. S., Steinfath, M., Doka, J., Afework Tesfahunegn, Y., Violet, N., Renko, K., Gulich, K., John, T., Schneider, M. R., Wistorf, E., Schönfelder, G., Schulze, F. (2023) A microphysiological system for studying human bone biology under simultaneous control of oxygen tension and mechanical loading. Lab on a Chip, 2023 July 3. https://doi.org/10.1039/D3LC00154G

Teixidó, E., Riera-Colomer, C., Raldúa, D., Pubill, D., Escubedo, E., Barenys, M. and López-Arnau, R. (2023). First generation synthetic cathinones produce arrhythmia in zebrafish eleutheroembryos. A New Approach Methodology for New Psychoactive Substances cardiotoxicity evaluation. International Journal of Molecular Sciences. http://dx.doi.org/https://doi.org/10.3390/ijms241813869

Uluckan, Ö., Bruno, S., Wang, Y., Wack, N., Wilzopolski, J., Goetschy, J.-F., Delucis-Bronn, C., Urban, B., Fehlmann, D., Stark, H., Hauchard, A., Roussel, E., Kempf, D., Kaupmann, K., Raulf, F., Bäumer, W., Röhn, T. A. and Zerwes, H. G. (2023). Adriforant is a functional antagonist of histamine receptor 4 and attenuates itch and skin inflammation in mice. European Journal of Pharmacology 945, 175533. http://dx.doi.org/10.1016/j.ejphar.2023.175533

Wagenknecht, T., Eusemann, B., Schwedhelm, P., Schönfelder, G. and Bert, B. (2023). Das Vorliegen eines “vernünftigen Grundes” bei der Tötung überzähliger Versuchstiere. Natur und Recht 45, 225–233. https://doi.org/10.1007/s10357-022-4103-8

Wagenknecht, T., Eusemann, B., Schwedhelm, P., Schönfelder, G., Bert, B. (2023) Die Tötung überzähliger Versuchstiere – das Erfordernis des „vernünftigen Grundes“ und die Übertragung aktueller Rechtsprechung auf den Versuchstierbereich. Natur und Recht, Januar 2023, 45, 22-30, https://doi.org/10.1007/s10357-022-4102-9

Weber, A.G., Birk, B., Giri, V., Hoffmann, S., Renko, K., Coecke, S., Schneider, S., Funk-Weyer, D., and Landsiedel, R. (2023) Assessment of the Predictivity of DIO1-SK Assay to Investigate DIO1 Inhibition in Human Liver Microsomes. Applied In Vitro Toxicology, Vol. 9, No. 2, 15 June 2023.
https://doi.org/10.1089/aivt.2022.0016

Wessels, L., Kjellevold, M., Kolding, J., Odoli, C., Aakre, I., Reich, F. and Pucher, J. (2023). Putting small fish on the table: The underutilized potential of small indigenous fish to improve food and nutrition security in East Africa. Food Security. http://dx.doi.org/https://doi.org/10.1007/s12571-023-01362-8

Wewetzer, H., Wagenknecht, T., Bert, B. and Schönfelder, G. (2023). The fate of surplus laboratory animals. EMBO Reports 24, :e56551. http://dx.doi.org/10.15252/embr.202256551

Wilhelmi, P., Giri, V., Zickgraf, F. M., Haake, V., Henkes, S., Driemert, P., Michaelis, P., Busch, W., Scholz, S., Flick, B., Barenys, M., Birk, B., Kamp, H., Landsiedel, R. and Funk-Weyer, D. (2023). A metabolomics approach to reveal the mechanism of developmental toxicity in zebrafish embryos exposed to 6-propyl-2-thiouracil. Chemico-Biological Interactions 382. http://dx.doi.org/https://doi.org/10.1016/j.cbi.2023.110565

Wilzopolski, J., Putrianti, E., Balik, P., Goerlich, S., Lindner, T. and Ohnesorge, N. (2023). Assessment of the antinociceptive efficacy of analgesics, anesthetics and other compounds in zebrafish (Danio rerio). Journal of Veterinary Pharmacology and Therapeutics 46(S1):45-45. http://dx.doi.org/10.1111/jvp.13202

Wolter, A., Bucher, C. H., Kurmies, S., Schreiner, V., Konietschke, F., Hohlbaum, K., Klopfleisch, R., Löhning, M., Thöne-Reineke, C., Buttgereit, F., Huwyler, J., Jirkof, P., Rapp, A. E. and Lang, A. (2023). A buprenorphine depot formulation provides effective sustained post-surgical analgesia for 72 h in mouse femoral fracture models. Scientific Reports 13 (1), 3824. http://dx.doi.org/10.1038/s41598-023-30641-9

2022:

Bühler, M., Fahrländer, J., Sauter, A., Becker, M., Wistorf, E., Steinfath, M. and Stolz, A. (2022). GPER1 links estrogens to centrosome amplification and chromosomal instability in human colon cells. Life Science Alliance, 6 (1), e202201499. http://dx.doi.org/10.26508/lsa.202201499

Bühler, M. & Stolz, A. (2022) Estrogens – Origin of Centrosome Defects in Human cancer? Cells, 11(3), 432. https://doi.org/10.3390/cells11030432

Deng, D. & Zi, Z. (2022). Absolute Quantification of TGF-beta Signaling Proteins Using Quantitative Western Blot. In: Z. Zi and X. Liu. TGF-Beta Signaling. Methods and Protocols. Methods in Molecular Biology, 2488. Humana, New York, NY. 1-12. http://dx.doi.org/10.1007/978-1-0716-2277-3_1

Diederich, K., Schmitt, K., Schwedhelm, P., Bert, B. and Heinl, C. (2022). A guide to open science practices for animal research. PLOS Biology, 20 (9), e3001810. http://dx.doi.org/10.1371/journal.pbio.3001810

Engel, A. M., Klevenhusen, F., Moenning, J.-L., Numata, J., Fischer-Tenhagen, C., Sachse, B., Scha?fer, B., Fry, H., Kappenstein, O. and Pieper, R. (2022). Investigations on the Transfer of Quinolizidine Alkaloids from Lupinus angustifolius into the Milk of Dairy Cows. Journal of Agricultural and Food Chemistry, 70 (37), 11749–11758. http://dx.doi.org/10.1021/acs.jafc.2c02517

 Escher, B. I., Lamoree, M., Antignac, J.-P., Scholze, M., Herzler, M., Hamers, T., Jensen, T. K., Audebert, M., Busquet, F., Maier, D., Oelgeschläger, M., Valente, M. J., Boye, H., Schmeisser, S., Dervilly, G., Piumatti, M., Motteau, S., König, M., Renko, K., Margalef, M., Cariou, R., Ma, Y., Treschow, A. F., Kortenkamp, A. and Vinggaard, A. M. (2022). Mixture Risk Assessment of Complex Real-Life Mixtures-The PANORAMIX Project. International Journal of Environmental Research and Public Health, 19 (20), 12990. http://dx.doi.org/10.3390/ijerph192012990

 Fischer-Tenhagen, C., Meier, J. and Pohl, A. (2022). “Do not look at me like that”: Is the facial expression score reliable and accurate to evaluate pain in large domestic animals? A systematic review. Frontiers in Veterinary Science, 9, 1002681. http://dx.doi.org/10.3389/fvets.2022.1002681

Graffunder, A. S., Paisdzior, S., Opitz, R., Renko, K., Kühnen, P. & Biebermann, H. (2022). Design and Characterization of a Fluorescent Reporter Enabling Live-cell Monitoring of MCT8 Expression. Experimental and Clinical Endocrinology & Diabetes, 130 (02), 134-140. http://dx.doi.org/10.1055/a-1522-8535

Habedank, A., Urmersbach, B., Kahnau, P. and Lewejohann, L. (2022). O mouse, where art thou? The Mouse Position Surveillance System (MoPSS) - an RFID-based tracking system. Behavior Research Methods, 54 (2), 676–689. http://dx.doi.org/10.3758/s13428-021-01593-7

Heinl, C., Schönfelder, G. and Bert, B. (2022). Preregistration in Animal Research. In: J. Faintuch and S. Faintuch Integrity of Scientific Research: Fraud, Misconduct and Fake News in the Academic, Medical and Social Environment. 371-378. Springer. http://dx.doi.org/10.1007/978-3-030-99680-2_37

Heinl, C., Scholman-Végh, A. M. D., Mellor, D., Schönfelder, G., Strech, D., Chamuleau, S. & Bert, B. (2022). Declaration of common standards for the preregistration of animal research – speeding up the scientific progress. PNAS Nexus, pgac016. http://dx.doi.org/10.1093/pnasnexus/pgac016

Jacobs, M. N., Ezendam, J., Hakkert, B., Oelgeschläger, M. & Hakkert, B. (2022). Potential of concentration-response data to broaden regulatory application of in vitro test guidelines. ALTEX - Alternatives to Animal Experimentation. http://dx.doi.org/10.14573/altex.2107091

Kahnau, P., Jaap, A., Hobbiesiefken, U., Mieske, P., Diederich, K., Thöne-Reineke, C., Lewejohann, L. and Hohlbaum, K. (2022). A preliminary survey on the occurrence of barbering in laboratory mice in Germany. Animal Welfare, 31 (4), 433-436. http://dx.doi.org/10.7120/09627286.31.4.009

Klutzny, S., Kornhuber, M., Morger, A., Schönfelder, G., Volkamer, A., Oelgeschläger, M. & Dunst, S. (2022). Quantitative high-throughput phenotypic screening for environmental estrogens using the E-Morph Screening Assay in combination with in silico predictions. Environment International, 158, 106947.http://dx.doi.org/10.1016/j.envint.2021.106947

Körber, N. (2022). MIA: An Open Source Standalone Deep Learning Application for Microscopic Image Analysis. bioRxiv. http://dx.doi.org/10.1101/2022.01.14.476308

Kohler, J., Mei, J., Banneke, S., Winter, Y., Endres, M. and Emmrich, J. V. (2022). Assessing spatial learning and memory in mice: Classic radial maze versus a new animal-friendly automated radial maze allowing free access and not requiring food deprivation. Frontiers in Behavioral Neuroscience, 16, 1013624. http://dx.doi.org/10.3389/fnbeh.2022.1013624

Kornhuber, M. & Dunst, S. (2022). Automated Classification of Cellular Phenotypes Using Machine Learning in Cellprofiler and CellProfiler Analyst. In: Z. Zi and X. Liu. TGF-Beta Signaling. Methods and Protocols. Methods in Molecular Biology, 2488. Humana, New York, NY. 1-12. http://dx.doi.org/10.1007/978-1-0716-2277-3_14

Li, Y. & Zi, Z. (2022). Optogenetic Control of TGF-beta Signaling. In: Z. Zi and X. Liu. TGF-Beta Signaling. Methods and Protocols. Methods in Molecular Biology, 2488. Humana, New York, NY. 113-124.http://dx.doi.org/10.1007/978-1-0716-2277-3_9

Mackert, O., Wirth, E.K., Sun, R., Winkler, J., Liu, A., Renko, K., Kunz, S., Spranger, J. & Brachs, S. (2022). Impact of metabolic stress induced by diets, aging and fasting on tissue oxygen consumption. Molecular Metabolism, 64: 101563. https://doi.org/10.1016/j.molmet.2022.101563

Mieske, P., Hobbiesiefken, U., Fischer-Tenhagen, C., Heinl, C., Hohlbaum, K., Kahnau, P., Meier, J., Wilzopolski, J., Butzke, D., Rudeck, J., Lewejohann, L. & Diederich, K. (2022). Bored at home?—A systematic review on the effect of environmental enrichment on the welfare of laboratory rats and mice, Frontiers in Veterinary Science, 9. https://doi.org/10.3389/fvets.2022.899219

Mihelakis, M., Ndikung, J., Oelgeschläger, M. & Ertych, N. (2022). The 4th dimension of in vitro systems - Time to level up. Environment International, 164, 107256. http://dx.doi.org/10.1016/j.envint.2022.107256

Neves, M., Yepes, A. J., Siu, A., Roller, R., Thomas, P., Navarro, M. V., Yeganova, L., Wiemann, D., Di Nunzio, G. M., Vezzani, F., Gerardin, C., Bawden, R., Estrada, D. J., Lima-López, S., Farré-Maduell, E., Krallinger, M., Grozea, C. and Névéol, A. (2022). Findings of the WMT 2022 Biomedical Translation Shared Task: Monolingual Clinical Case Reports. Proceedings of the Seventh Conference on Machine Translation (WMT), 694-723.

Niethammer, M., Burgdorf, T., Wistorf, E., Schönfelder, G. and Kleinsorge, M. (2022). In vitro models of human development and their potential application in developmental toxicity testing. Development, 149 (20), dev200933. http://dx.doi.org/10.1242/dev.200933

Renko, K., Kerp, H., Pape, J., Rijntjes, E., Burgdorf, T., Führer, D. & Köhrle, J. (2022). Tentative Application of a Streamlined Protocol to Determine Organ-Specific Regulations of Deiodinase 1 and Dehalogenase Activities as Readouts of the Hypothalamus-Pituitary-Thyroid-Periphery-Axis. Frontiers in Toxicology, 4, 822993. http://dx.doi.org/10.3389/ftox.2022.822993

Tappe-Theodor, A., Pitzer, C., Lewejohann, L., Jirkof, P., Siegeler, K., Segelcke, A., Drude, N., Pradier, B., Pogatzki-Zahn, E., Hollinderbaumer, B. & Segelcke, D. (2022). The "WWHow" Concept for Prospective Categorization of Post-operative Severity Assessment in Mice and Rats. Frontiers in Veterinary Science, 9, 841431. http://dx.doi.org/10.3389/fvets.2022.841431

Weber, A. G., Birk, B., Herrmann, C., Huener, H.-A., Renko, K., Coecke, S., Schneider, S., Funk-Weyer, D. and Landsiedel, R. (2022). A New Approach Method to Study Thyroid Hormone Disruption: Optimization and Standardization of an Assay to Assess the Inhibition of DIO1 Enzyme in Human Liver Microsomes. Applied In Vitro Toxicology, 8 (3), 67-82. http://dx.doi.org/10.1089/aivt.2022.0010

Zi, Z. & Liu, X. (2022). TGF-Beta Signaling. Methods in Molecular Biology, 2488. Humana, New York, NY. http://dx.doi.org/10.1007/978-1-0716-2277-3

2021:

Accuosto, P., Neves, M., & Saggion, H. (2021). Argumentation mining in scientific literature: from computational linguistics to biomedicine. http://repositori.upf.edu/handle/10230/47600

Akonor, P. T., Atter, A., Owusu, M., Ampah, J., Andoh?Odoom, A., Overå, R., Kjellevold, M., Pucher, J. & Kolding, J. (2021). Anchovy powder enrichment in brown rice?based instant cereal: a process optimization study using Response Surface Methodology (RSM). Food Science & Nutrition, 9 (8), 4485-4497. http://dx.doi.org/10.1002/fsn3.2424

Desaulniers, D., Vasseur, P., Jacobs, A., Aguila, M. C., Ertych, N. & Jacobs, M. N. (2021). Integration of Epigenetic Mechanisms into Non-Genotoxic Carcinogenicity Hazard Assessment: Focus on DNA Methylation and Histone Modifications. International Journal of Molecular Sciences, 22 (20), 10969. http://dx.doi.org/10.3390/ijms222010969

Graffunder, A. S., Paisdzior, S., Opitz, R., Renko, K., Kühnen, P., & Biebermann, H. (2021). Design and Characterization of a Fluorescent Reporter Enabling Live-cell Monitoring of MCT8 Expression. Experimental and Clinical Endocrinology & Diabetes. https://doi.org/10.1055/a-1522-8535

Habedank, A., Kahnau, P. & Lewejohann, L. (2021). Alternate without alternative: neither preference nor learning explains behaviour of C57BL/6J mice in the T-maze. Behaviour, 158 (7), 625-662. http://dx.doi.org/10.1163/1568539X-bja10085

Habedank, A., Urmersbach, B., Kahnau, P., & Lewejohann, L. (2021). O mouse, where art thou? The Mouse Position Surveillance System (MoPSS)-an RFID-based tracking system. Behavior Research Methods. https://doi.org/10.3758/s13428-021-01593-7

Hobbiesiefken, U., Mieske, P., Lewejohann, L. & Diederich, K. (2021). Evaluation of different types of enrichment their usage and effect on home cage behavior in female mice. PLoS ONE, 16 (12), e0261876. http://dx.doi.org/10.1371/journal.pone.0261876

Hobbiesiefken, U., Urmersbach, B., Jaap, A., Diederich, K. & Lewejohann, L. (2021). Rating enrichment items by group-housed laboratory mice in multiple binary choice tests using an RFID-based tracking system. bioRxiv. http://dx.doi.org/10.1101/2021.10.20.465117

Kahnau, P., Guenther, A., Boon, M. N., Terzenbach, J. D., Hanitzsch, E., Lewejohann, L. & Brust, V. (2021). Lifetime Observation of Cognition and Physiological Parameters in Male Mice. frontiers in Behavioral Neuroscience, 15, 709775. http://dx.doi.org/10.3389/fnbeh.2021.709775

Kerp, H., Renko, K., Hönes, G. S., Brix, K., Köhrle, J., Moeller, L. C., & Fuehrer, D. (2021). Age dependent response to T4 overtreatment and recovery on systemic and organ level. Journal of Molecular Endocrinology. https://doi.org/10.1530/JME-21-0109

Klutzny, S., Kornhuber, M., Morger, A., Schönfelder, G., Volkamer, A., Oelgeschläger, M. & Dunst, S. (2021). Quantitative high-throughput phenotypic screening for environmental estrogens using the E-Morph Screening Assay in combination with in silico predictions. Environment International, 158, 106947. http://dx.doi.org/10.1016/j.envint.2021.106947

Kornhuber, M., Dunst, S., Schönfelder, G., & Oelgeschläger, M. (2021). The E-Morph Assay: Identification and characterization of environmental chemicals with estrogenic activity based on quantitative changes in cell-cell contact organization of breast cancer cells. Environment International, 149, 106411. https://doi.org/10.1016/j.envint.2021.106411

Li, Y., Lee, H., Heo, W. D. & Zi, Z. (2021). Revisiting the Role of TGFβ Receptor Internalization for Smad Signaling: It is Not Required in Optogenetic TGFβ Signaling Systems. Advanced Biology, 5 (10), 2101008. http://dx.doi.org/10.1002/adbi.202101008

Lossow, K., Renko, K., Schwarz, M., Kopp, J. F., Schomburg, L., Schwerdtle, T. & Kipp, A. P. (2021). The Nutritional Supply of Iodine and Selenium Affects Thyroid Hormone Axis Related Endpoints in Mice. Nutrients, 13 (11), 3773. http://dx.doi.org/10.3390/nu13113773

Marx-Stoelting, P., Solano, M.L.R., Aoyama, H., Adams R.H., Bal-Price A.,, Buschmann, J., Chahoud, I., Clark, R., Fang, T., Fujiwara, M., Gelinsky, M., Grote, K., Horimoto, M., Bennekou, S.H., Kellner, R., Kuwagata, M., Leist, M., Lang, A., Li, W., Mantovani, A., Makris, S.L., Paumgartten, F., Perron, M., Sachana, M., Schmitt, A., Schneider, S., Schönfelder,. G, Schulze, F., Shiota, K., Solecki, R. (2021). 25th anniversary of the Berlin workshop on developmental toxicology: DevTox database update, challenges in risk assessment of developmental neurotoxicity and alternative methodologies in bone development and growth. Reprod Toxicol, 100, 155-162. https://doi.org/10.1016/j.reprotox.2020.11.003

Mieske, P., Diederich, K. & Lewejohann, L. (2021). Roaming in a Land of Milk and Honey: Life Trajectories and Metabolic Rate of Female Inbred Mice Living in a Semi Naturalisitc Environment. animals, 11 (10), 3002. http://dx.doi.org/10.3390/ani11103002

Neves, M., & Ševa, J. (2021). An extensive review of tools for manual annotation of documents. Briefings in Bioinformatics, 22(1), 146–163. https://doi.org/10.1093/bib/bbz130

Ohnesorge, N., Heinl, C., & Lewejohann, L. (2021). Current Methods to Investigate Nociception and Pain in Zebrafish. Frontiers in Neuroscience, 15, 632634. https://doi.org/10.3389/fnins.2021.632634

Olevska, A., Bert, B., Ebrahimi, L., Schönfelder, G., & Heinl, C. (2021). Ensuring Reproducible Research Requires a Support Infrastructure: The Value of Public Registries to Publishers. Science Editor, 4–7. https://doi.org/10.36591/SE-D-4401-4

Schmerbeck, S., Schulze, F., Scheinpflug, J., Ebrahimi, L. (2021). Organ-on-chip systems and the 3Rs. Science in School, 54, 1-4. https://www.scienceinschool.org/article/2021/organ-on-chip/

Schneider, M. R. (2021). Losing fat through the skin. Science (New York, N.Y.), 373(6554), 487–488. https://doi.org/10.1126/science.abg9079

Schneider, M. R., Oelgeschläger, M., Burgdorf, T., van Meer, P., Theunissen, P., Kienhuis, A. S., Persma. A. H., Vandebriel, R. J. (2021). Applicability of organ-on-chip systems in toxicology and pharmacology. Crit Rev Toxicol, 1-15.  https://doi.org/10.1080/10408444.2021.1953439

Schönfelder, G., Oelgeschläger, M., Bischoff, P., Kornhuber, M., Dunst, S. & Vogl, S. (2021). Screening Method for Estrogenic and Anti-Estrogenic Activity. Patent Application Publication. https://scholar.google.com/citations?view_op=view_citation&hl=de&user=vdN9E_oAAAAJ&sortby=pubdate&citation  _for_view=vdN9E_oAAAAJ:5Ul4iDaHHb8C

Schwedhelm, P., Kusnick, J., Heinl, C., Schönfelder, G., Bert, B. (2021). How many animals are used for SARS-CoV-2 research? EMBO reports, e53751. https://doi.org.10.15252/embr.202153751

Stevens, C., Hawkins, P., Smulders, T. V., MacLellan, A., Lewejohann, L., Jirkof, P., Boxall, J., Murphy, H., Moody, C. M., Turner, P. V., Makowska, J. I. & Inman, C. (2021). Report of the 2020 RSPCA/UFAW rodent and rabbit welfare meeting. Animal Technology and Welfare. https://journal.atwjournal.com/atwapril2021#page=7

Sun, Q., Mehl, S., Renko, K., Seemann, P., Görlich, C. L., Hackler, J., Minich, W. B., Kahaly, G. J. & Schomburg, L. (2021). Natural Autoimmunity to Selenoprotein P Impairs Selenium Transport in Hashimoto's Thyroiditis. International Journal of Molecular Sciences, 22 (23), 13088. http://dx.doi.org/10.3390/ijms222313088

Tappe-Theodor, A., Pitzer, C., Lewejohann, L., Jirkof, P., Siegeler, K., Segelcke, A., Drude, N., Pradier, B., Pogatzki-Zahn, E., Hollinderbäumer, B. & Segelcke, D. (2021). The "WWHow" concept for prospective categorization of post-operative severity assessment in rodents. ResearchGate. http://dx.doi.org/10.13140/RG.2.2.14852.86408

Tralau, T., Oelgeschläger, M., Kugler, J., Bloch, D., Braeuning, A., Burgdorf, T., Marx-Stoelting, P., Ritz, V., Schmeisser, S., Trubiroha, A., Zellmer, S., Luch, A., Schönfelder, G., Solecki, R., & Hensel, A. (2021). A prospective whole-mixture approach to assess risk of the food and chemical exposome. Nature Food, 2(7), 463–468. https://doi.org/10.1038/s43016-021-00316-7

Van der Mierden, S., Leenaars, C. H. C., Boyle, E. C., Ripoli, F. L., Gass, P., Durst, M., Goerlich-Jansson, V. C., Jirkof, P., Keubler, L. M., Talbot, S. R., Habedank, A., Lewejohann, L., Tolba, R. H., & Bleich, A. (2021). Measuring endogenous corticosterone in laboratory mice - a mapping review, meta-analysis, and open source database. ALTEX, 38(1), 111–122. https://doi.org/10.14573/altex.2004221

Voß, A. L., Heuwieser, W., Mee, J. F. & Fischer-Tenhagen, C. (2021). Calving Management: A Questionnaire Survey of Veterinary Subject Matter Experts and Non-Experts. animals, 11 (11), 3129. http://dx.doi.org/10.3390/ani11113129

Wessels, L., Reich, F., Schmoger, S., Pucher, J., Atter, A., Käsbohrer, A., & Hammerl, J. A. (2021). Draft Genome Sequences of Pseudomonas sp. Isolates Recovered from Ghanaian Fish Food Samples in 2018. Microbiology Resource Announcements, 10(6). https://doi.org/10.1128/MRA.01332-20

2020:

Andresen, N., Wöllhaf, M., Hohlbaum, K., Lewejohann, L., Hellwich, O., Thöne-Reineke, C., & Belik, V. (2020). Towards a fully automated surveillance of well-being status in laboratory mice using deep learning: Starting with facial expression analysis. PloS One, 15(4), e0228059. https://doi.org/10.1371/journal.pone.0228059

Ban, Z., Knöspel, F., & Schneider, M. R. (2020). Shedding light into the black box: Advances in in vitro systems for studying implantation. Developmental Biology, 463(1), 1–10. https://doi.org/10.1016/j.ydbio.2020.04.003

Bawden, R., Nunzio, G. D., Grozea, C., Unanue, I., Yepes, A., Mah, N., Martinez, D., Névéol, A., Neves, M., Oronoz, M., Viñaspre, O. P. de, Piccardi, M., Roller, R., Siu, A., Thomas, P., Vezzani, F., Navarro, M., Wiemann, D., & Yeganova, L. (2020). Findings of the WMT 2020 Biomedical Translation Shared Task: Basque, Italian and Russian as New Additional Languages. 5th Conference on Machine Translation. https://hal.inria.fr/hal-02986356

Bischoff, P., Kornhuber, M., Dunst, S., Zell, J., Fauler, B., Mielke, T., Taubenberger, A. V., Guck, J., Oelgeschläger, M., & Schönfelder, G. (2020). Estrogens Determine Adherens Junction Organization and E-Cadherin Clustering in Breast Cancer Cells via Amphiregulin. IScience, 23(11), 101683. https://doi.org/10.1016/j.isci.2020.101683

Burow, E., Grobbel, M., Tenhagen, B.-A., Simoneit, C., Szabó, I., Wendt, D., Kürbis, C., Ladwig-Wiegard, M., Banneke, S., & Käsbohrer, A. (2020). Antibiotic Resistance in Escherichia coli from Broiler Chickens After Amoxicillin Treatment in an Experimental Environment. Microbial Drug Resistance (Larchmont, N.Y.), 26(9), 1098–1107. https://doi.org/10.1089/mdr.2019.0442

Clayton, R. W., Langan, E. A., Ansell, D. M., de Vos, I. J. H. M., Göbel, K., Schneider, M. R., Picardo, M., Lim, X., van Steensel, M. A. M., & Paus, R. (2020). Neuroendocrinology and neurobiology of sebaceous glands. Biological Reviews of the Cambridge Philosophical Society, 95(3), 592–624. https://doi.org/10.1111/brv.12579

Heinl, C., Chmielewska, J., Olevska, A., Grune, B., Schönfelder, G., & Bert, B. (2020). Rethinking the incentive system in science: animal study registries: Preregistering experiments using animals could greatly improve transparency and reliability of biomedical studies and improve animal welfare. EMBO Reports, 21(1), e49709. https://doi.org/10.15252/embr.201949709

Jacobs, M. N., Colacci, A., Corvi, R., Vaccari, M., Aguila, M. C., Corvaro, M., Delrue, N., Desaulniers, D., Ertych, N., Jacobs, A., Luijten, M., Madia, F., Nishikawa, A., Ogawa, K., Ohmori, K., Paparella, M., Sharma, A. K., & Vasseur, P. (2020). Chemical carcinogen safety testing: OECD expert group international consensus on the development of an integrated approach for the testing and assessment of chemical non-genotoxic carcinogens. Archives of Toxicology, 94(8), 2899–2923. https://doi.org/10.1007/s00204-020-02784-5

Kahnau, P., Habedank, A., Diederich, K., & Lewejohann, L. (2020). Behavioral Methods for Severity Assessment. Animals, 10(7). https://doi.org/10.3390/ani10071136

Leenaars, C. H. C., van der Mierden, S., Durst, M., Goerlich-Jansson, V. C., Ripoli, F. L., Keubler, L. M., Talbot, S. R., Boyle, E., Habedank, A., Jirkof, P., Lewejohann, L., Gass, P., Tolba, R., & Bleich, A. (2020). Measurement of corticosterone in mice: a protocol for a mapping review. Laboratory Animals, 54(1), 26–32. https://doi.org/10.1177/0023677219868499

Lewejohann, L., Grune, B., Schönfelder, G., & Bert, B. (2020). Cut back on surplus laboratory animals. Nature, 578(7796), 515. https://doi.org/10.1038/d41586-020-00517-3

Lewejohann, L., Schwabe, K., Häger, C., & Jirkof, P. (2020). Impulse for animal welfare outside the experiment. Laboratory Animals, 54(2), 150–158. https://doi.org/10.1177/0023677219891754

Mei, J., Kohler, J., Winter, Y., Spies, C., Endres, M., Banneke, S., & Emmrich, J. V. (2020). Automated radial 8-arm maze: A voluntary and stress-free behavior test to assess spatial learning and memory in mice. Behavioural Brain Research, 381, 112352. https://doi.org/10.1016/j.bbr.2019.112352

Ndikung, J., Storm, D., Violet, N., Kramer, A., Schönfelder, G., Ertych, N., & Oelgeschläger, M. (2020). Restoring circadian synchrony in vitro facilitates physiological responses to environmental chemicals. Environment International, 134, 105265. https://doi.org/10.1016/j.envint.2019.105265

Névéol, A., Jimeno Yepes, A., & Neves, M. L. (2020). MEDLINE as a parallel corpus: a survey to gain insight on French-, Spanish- and Portuguese-speaking authors’ abstract writing practice. In ELRA (Ed.), International Conference on Language Resources and Evaluation. https://hal.archives-ouvertes.fr/hal-03023950

Neves, M. (2020). Integration of the PubAnnotation ecosystem in the development of a web-based search tool for alternative methods. Genomics & Informatics, 18(2), e18. https://doi.org/10.5808/GI.2020.18.2.e18

Neves, M., & Seva, J. (2020). Annotationsaurus: A Searchable Directory of Annotation Tools. ArXiv:2010.06251 [Cs]. http://arxiv.org/abs/2010.06251

Rudeck, J., Vogl, S., Banneke, S., Schönfelder, G., & Lewejohann, L. (2020). Repeatability analysis improves the reliability of behavioral data. PloS One, 15(4), e0230900. https://doi.org/10.1371/journal.pone.0230900

Rudeck, J., Vogl, S., Heinl, C., Steinfath, M., Fritzwanker, S., Kliewer, A., Schulz, S., Schönfelder, G., & Bert, B. (2020). Analgesic treatment with buprenorphine should be adapted to the mouse strain. Pharmacology, Biochemistry, and Behavior, 191, 172877. https://doi.org/10.1016/j.pbb.2020.172877

Stolz, A., Becker, M., Wistorf, E., & Ertych, N. (2020). Biomedical Research Meets Toxicology: How In Vitro Chromosome Instability Methods Can Contribute to Carcinogenicity Prediction. Cancer Research, 80(8), 1626–1629. https://doi.org/10.1158/0008-5472.CAN-19-2822

van Jaarsveld, M. T. M., Deng, D., Ordoñez-Rueda, D., Paulsen, M., Wiemer, E. A. C., & Zi, Z. (2020). Cell-type-specific role of CHK2 in mediating DNA damage-induced G2 cell cycle arrest. Oncogenesis, 9(3), 35. https://doi.org/10.1038/s41389-020-0219-y

Weegh, N., Füner, J., Janke, O., Winter, Y., Jung, C., Struve, B., Wassermann, L., Lewejohann, L., Bleich, A., & Häger, C. (2020). Wheel running behaviour in group-housed female mice indicates disturbed wellbeing due to DSS colitis. Laboratory Animals, 54(1), 63–72. https://doi.org/10.1177/0023677219879455

Wistorf, E., Knöspel, F., Schönfelder, G., & Schneider, M. R. (2020). 3R-related research funding: Insights from a meeting hosted by the German Centre for the Protection of Laboratory Animals (Bf3R). ALTEX, 37(2), 320–323. https://doi.org/10.14573/altex.2002201

Wittkowski, P., Violet, N., Oelgeschläger, M., Schönfelder, G., & Vogl, S. (2020). A quantitative medium-throughput assay to measure Caenorhabditis elegans development and reproduction. STAR Protocols, 1(3), 100224. https://doi.org/10.1016/j.xpro.2020.100224

Zhang, X., Xu, Q., Zi, Z., Liu, Z., Wan, C., Crisman, L., Shen, J., & Liu, X. (2020). Programmable Extracellular Vesicles for Macromolecule Delivery and Genome Modifications. Developmental Cell, 55(6), 784-801.e9. https://doi.org/10.1016/j.devcel.2020.11.007

Zouboulis, C. C., Yoshida, G. J., Wu, Y., Xia, L., & Schneider, M. R. (2020). Sebaceous gland: Milestones of 30-year modelling research dedicated to the “brain of the skin”. Experimental Dermatology, 29(11), 1069–1079. https://doi.org/10.1111/exd.14184

2019:

Bawden, R., Bretonnel Cohen, K., Grozea, C., Jimeno Yepes, A., Kittner, M., Krallinger, M., Mah, N., Neveol, A., Neves, M., Soares, F., Siu, A., Verspoor, K., & Vicente Navarro, M. (2019). Findings of the WMT 2019 Biomedical Translation Shared Task: Evaluation for MEDLINE Abstracts and Biomedical Terminologies. Proceedings of the Fourth Conference on Machine Translation (Volume 3: Shared Task Papers, Day 2), 29–53. https://doi.org/10.18653/v1/W19-5403

Bert, B., Heinl, C., Chmielewska, J., Schwarz, F., Grune, B., Hensel, A., Greiner, M., & Schönfelder, G. (2019). Refining animal research: The Animal Study Registry. PLoS Biology, 17(10), e3000463. https://doi.org/10.1371/journal.pbio.3000463

Burgdorf, T., Piersma, A. H., Landsiedel, R., Clewell, R., Kleinstreuer, N., Oelgeschläger, M., Desprez, B., Kienhuis, A., Bos, P., de Vries, R., de Wit, L., Seidle, T., Scheel, J., Schönfelder, G., van Benthem, J., Vinggaard, A. M., Eskes, C., & Ezendam, J. (2019). Workshop on the validation and regulatory acceptance of innovative 3R approaches in regulatory toxicology - Evolution versus revolution. Toxicology in Vitro, 59, 1–11. https://doi.org/10.1016/j.tiv.2019.03.039

Chmielewska, J., Bert, B., Grune, B., & Schönfelder, G. (2019). Rechtliche Aspekte der Anwendung des pharmakologisch wirksamen Stoffs Tamoxifen bei der konditionellen Genausschaltung im Versuchstier Maus. Natur Und Recht, 41(1), 26–32. https://doi.org/10.1007/s10357-018-3457-4

Dunst, S., & Tomancak, P. (2019). Imaging Flies by Fluorescence Microscopy: Principles, Technologies, and Applications. Genetics, 211(1), 15–34. https://doi.org/10.1534/genetics.118.300227

Heberle, A. M., Razquin Navas, P., Langelaar-Makkinje, M., Kasack, K., Sadik, A., Faessler, E., Hahn, U., Marx-Stoelting, P., Opitz, C. A., Sers, C., Heiland, I., Schäuble, S., & Thedieck, K. (2019). The PI3K and MAPK/p38 pathways control stress granule assembly in a hierarchical manner. Life Science Alliance, 2(2). https://doi.org/10.26508/lsa.201800257

Jirkof, P., Rudeck, J., & Lewejohann, L. (2019). Assessing Affective State in Laboratory Rodents to Promote Animal Welfare-What Is the Progress in Applied Refinement Research? Animals, 9(12). https://doi.org/10.3390/ani9121026

Kelly, L., Goeuriot, L., Suominen, H., Neves, M., Kanoulas, E., Spijker, R., Azzopardi, L., Li, D., Jimmy, Palotti, J., & Zuccon, G. (2019). CLEF eHealth 2019 Evaluation Lab. In L. Azzopardi, B. Stein, N. Fuhr, P. Mayr, C. Hauff, & D. Hiemstra (Eds.), Advances in Information Retrieval (pp. 267–274). Springer International Publishing. https://doi.org/10.1007/978-3-030-15719-7_36

Kelly, L., Suominen, H., Goeuriot, L., Neves, M., Kanoulas, E., Li, D., Azzopardi, L., Spijker, R., Zuccon, G., Scells, H., & Palotti, J. (2019). Overview of the CLEF eHealth Evaluation Lab 2019. In F. Crestani, M. Braschler, J. Savoy, A. Rauber, H. Müller, D. E. Losada, G. Heinatz Bürki, L. Cappellato, & N. Ferro (Eds.), Experimental IR Meets Multilinguality, Multimodality, and Interaction (pp. 322–339). Springer International Publishing. https://doi.org/10.1007/978-3-030-28577-7_26

Knebel, C., Heise, T., Zanger, U. M., Lampen, A., Marx-Stoelting, P., & Braeuning, A. (2019). The azole fungicide tebuconazole affects human CYP1A1 and CYP1A2 expression by an aryl hydrocarbon receptor-dependent pathway. Food and Chemical Toxicology, 123, 481–491. https://doi.org/10.1016/j.fct.2018.11.039

Knöspel, F., Ban, Z., Schönfelder, G., & Schneider, M. R. (2019). Next milestone in understanding early life-blastoids mimic embryogenesis in vitro. Biology of Reproduction, 100(1), 11–12. https://doi.org/10.1093/biolre/ioy182

Mei, J., Banneke, S., Lips, J., Kuffner, M. T. C., Hoffmann, C. J., Dirnagl, U., Endres, M., Harms, C., & Emmrich, J. V. (2019). Refining humane endpoints in mouse models of disease by systematic review and machine learning-based endpoint definition. ALTEX, 36(4), 555–571. https://doi.org/10.14573/altex.1812231

Neves, M., Butzke, D., & Grune, B. (2019). Evaluation of Scientific Elements for Text Similarity in Biomedical Publications. Proceedings of the 6th Workshop on Argument Mining, 124–135. https://doi.org/10.18653/v1/W19-4515

Schulze, F., Schneider, M.R. (2019). Hoffnung oder Humbug? Organ-on-a-chip in der biomedizinischen Forschung und als Alternative zum Tierversuch. Deutsches Tierärzteblatt, 67(10).

Solecki, R., Rauch, M., Gall, A., Buschmann, J., Kellner, R., Kucheryavenko, O., Schmitt, A., Delrue, N., Li, W., Hu, J., Fujiwara, M., Kuwagata, M., Mantovani, A., Makris, S.L., Paumgartten, F., Schönfelder, G., Schneider, S., Vogl, S., Kleinstreuer, N., Schneider, M., Schulze, F., Fritsche, E., Clark, R., Shiota, K., Chahoud, I. (2019) Update of the DevTox data database for harmonized risk assessment and alternative methodologies in developmental toxicology: Report of the 9th Berlin Workshop on Developmental Toxicity. Reprod Toxicol. 89, 124-129. https://doi.org/10.1016/j.reprotox.2019.07.003

Wittkowski, P., Marx-Stoelting, P., Violet, N., Fetz, V., Schwarz, F., Oelgeschläger, M., Schönfelder, G., & Vogl, S. (2019). Caenorhabditis elegans As a Promising Alternative Model for Environmental Chemical Mixture Effect Assessment-A Comparative Study. Environmental Science & Technology, 53(21), 12725–12733. https://doi.org/10.1021/acs.est.9b03266

2018:

Fetz, V., Stauber, R. H., & Knauer, S. K. (2018). Translocation Biosensors-Versatile Tools to Probe Protein Functions in Living Cells. Methods in Molecular Biology (Clifton, N.J.), 1683, 195–210. https://doi.org/10.1007/978-1-4939-7357-6_12

Hilse, K. E., Rupprecht, A., Egerbacher, M., Bardakji, S., Zimmermann, L., Wulczyn, A. E. M. S., & Pohl, E. E. (2018). The Expression of Uncoupling Protein 3 Coincides With the Fatty Acid Oxidation Type of Metabolism in Adult Murine Heart. Frontiers in Physiology, 9, 747. https://doi.org/10.3389/fphys.2018.00747

Knebel, C., Kebben, J., Eberini, I., Palazzolo, L., Hammer, H. S., Süssmuth, R. D., Heise, T., Hessel-Pras, S., Lampen, A., Braeuning, A., & Marx-Stoelting, P. (2018). Propiconazole is an activator of AHR and causes concentration additive effects with an established AHR ligand. Archives of Toxicology, 92(12), 3471–3486. https://doi.org/10.1007/s00204-018-2321-x

Knebel, C., Neeb, J., Zahn, E., Schmidt, F., Carazo, A., Holas, O., Pavek, P., Püschel, G. P., Zanger, U. M., Süssmuth, R., Lampen, A., Marx-Stoelting, P., & Braeuning, A. (2018). Unexpected Effects of Propiconazole, Tebuconazole, and Their Mixture on the Receptors CAR and PXR in Human Liver Cells. Toxicological Sciences, 163(1), 170–181. https://doi.org/10.1093/toxsci/kfy026

Lang, A., Volkamer, A., Behm, L., Röblitz, S., Ehrig, R., Schneider, M., Geris, L., Wichard, J., & Buttgereit, F. (2018). In silico methods - Computational alternatives to animal testing. ALTEX, 35(1), 124–126. https://doi.org/10.14573/altex.1712031

Mei, J., Riedel, N., Grittner, U., Endres, M., Banneke, S., & Emmrich, J. V. (2018). Body temperature measurement in mice during acute illness: implantable temperature transponder versus surface infrared thermometry. Scientific Reports, 8(1), 3526. https://doi.org/10.1038/s41598-018-22020-6

Moussallem, D., Ferreira, T. C., Zampieri, M., Cavalcanti, M. C., Xexéo, G., Neves, M., & Ngomo, A.-C. N. (2018). RDF2PT: Generating Brazilian Portuguese Texts from RDF Data. https://arxiv.org/abs/1802.08150

Neves, M., Butzke, D., Schönfelder, G., & Grune, B. (2018). Bf3R at SemEval-2018 Task 7: Evaluating Two Relation Extraction Tools for Finding Semantic Relations in Biomedical Abstracts. Proceedings of The 12th International Workshop on Semantic Evaluation, 816–820. https://doi.org/10.18653/v1/S18-1130

Neves, M., Jimeno Yepes, A., Névéol, A., Grozea, C., Siu, A., Kittner, M., & Verspoor, K. (2018). Findings of the WMT 2018 Biomedical Translation Shared Task: Evaluation on Medline test sets. Proceedings of the Third Conference on Machine Translation: Shared Task Papers, 324–339. https://doi.org/10.18653/v1/W18-6403

Piersma, A. H., Burgdorf, T., Louekari, K., Desprez, B., Taalman, R., Landsiedel, R., Barroso, J., Rogiers, V., Eskes, C., Oelgeschläger, M., Whelan, M., Braeuning, A., Vinggaard, A. M., Kienhuis, A., van Benthem, J., & Ezendam, J. (2018). Workshop on acceleration of the validation and regulatory acceptance of alternative methods and implementation of testing strategies. Toxicology in Vitro, 50, 62–74. https://doi.org/10.1016/j.tiv.2018.02.018

Rudeck, J., Bert, B., Marx-Stoelting, P., Schönfelder, G., & Vogl, S. (2018). Liver lobe and strain differences in the activity of murine cytochrome P450 enzymes. Toxicology, 404–405, 76–85. https://doi.org/10.1016/j.tox.2018.06.001

Salatzki, J., Foryst-Ludwig, A., Bentele, K., Blumrich, A., Smeir, E., Ban, Z., Brix, S., Grune, J., Beyhoff, N., Klopfleisch, R., Dunst, S., Surma, M. A., Klose, C., Rothe, M., Heinzel, F. R., Krannich, A., Kershaw, E. E., Beule, D., Schulze, P. C., … Kintscher, U. (2018). Adipose tissue ATGL modifies the cardiac lipidome in pressure-overload-induced left ventricular failure. PLoS Genetics, 14(1), e1007171. https://doi.org/10.1371/journal.pgen.1007171

Scheinpflug, J., Pfeiffenberger, M., Damerau, A., Schwarz, F., Textor, M., Lang, A., & Schulze, F. (2018). Journey into Bone Models: A Review. Genes, 9(5). https://doi.org/10.3390/genes9050247

Schneider, M. R., & Pincelli, C. (2018). The 3R approach to experimental dermatology. Experimental Dermatology, 27(5), 441–442. https://doi.org/10.1111/exd.13673

Schneider, M. R., & Zouboulis, C. C. (2018). Primary sebocytes and sebaceous gland cell lines for studying sebaceous lipogenesis and sebaceous gland diseases. Experimental Dermatology, 27(5), 484–488. https://doi.org/10.1111/exd.13513

Steinfath, M., Vogl, S., Violet, N., Schwarz, F., Mielke, H., Selhorst, T., Greiner, M., & Schönfelder, G. (2018). Simple changes of individual studies can improve the reproducibility of the biomedical scientific process as a whole. PLOS ONE, 13(9), e0202762. https://doi.org/10.1371/journal.pone.0202762

Stolz, A., Schönfelder, G., & Schneider, M. R. (2018). Endocrine Disruptors: Adverse Health Effects Mediated by EGFR? Trends in Endocrinology and Metabolism: TEM, 29(2), 69–71. https://doi.org/10.1016/j.tem.2017.12.003

2017:

Bert, B., Dörendahl, A., Leich, N., Vietze, J., Steinfath, M., Chmielewska, J., Hensel, A., Grune, B., & Schönfelder, G. (2017). Rethinking 3R strategies: Digging deeper into AnimalTestInfo promotes transparency in in vivo biomedical research. PLoS Biology, 15(12), e2003217. https://doi.org/10.1371/journal.pbio.2003217

Burgdorf, T., Dunst, S., Ertych, N., Fetz, V., Violet, N., Vogl, S., Schönfelder, G., Schwarz, F., & Oelgeschläger, M. (2017). The AOP Concept: How Novel Technologies Can Support Development of Adverse Outcome Pathways. Applied In Vitro Toxicology, 3(3), 271–277. https://doi.org/10.1089/aivt.2017.0011

Chmielewska, J., Bert, B., Grune, B., Hensel, A., & Schönfelder, G. (2017a). Probleme aus der tierversuchsrechtlichen Praxis: Rechtliche Einordnung der Genotypisierungsmethoden sowie der Zucht immunmodifizierter Tiere. Natur Und Recht, 39(6), 385–392. https://doi.org/10.1007/s10357-017-3190-4

Chmielewska, J., Bert, B., Grune, B., Hensel, A., & Schönfelder, G. (2017b). Rechtliche Probleme der Betäubung von Versuchstieren. Natur Und Recht, 39(8), 538–544. https://doi.org/10.1007/s10357-017-3212-2

Dahlhoff, M., Gaborit, N., Bultmann, S., Leonhardt, H., Yarden, Y., & Schneider, M. R. (2017). CRISPR-assisted receptor deletion reveals distinct roles for ERBB2 and ERBB3 in skin keratinocytes. The FEBS Journal, 284(19), 3339–3349. https://doi.org/10.1111/febs.14196

Herold, S., Krämer, D., Violet, N., & King, R. (2017). Rapid process synthesis supported by a unified modular software framework. Engineering in Life Sciences, 17(11), 1202–1214. https://doi.org/10.1002/elsc.201600020

Kodzius, R., Schulze, F., Gao, X., & Schneider, M. R. (2017). Organ-on-Chip Technology: Current State and Future Developments. Genes, 8(10). https://doi.org/10.3390/genes8100266

Schulze, F., Gao, X., Virzonis, D., Damiati, S., Schneider, M. R., & Kodzius, R. (2017). Air Quality Effects on Human Health and Approaches for Its Assessment through Microfluidic Chips. Genes, 8(10). https://doi.org/10.3390/genes8100244

Weidner, C., Steinfath, M., Wistorf, E., Oelgeschläger, M., Schneider, M. R., & Schönfelder, G. (2017). A Protocol for Using Gene Set Enrichment Analysis to Identify the Appropriate Animal Model for Translational Research. Journal of Visualized Experiments, 126, 55768. https://doi.org/10.3791/55768

2016:

Bert, B., Chmielewska, J., Bergmann, S., Busch, M., Driever, W., Finger?Baier, K., Hößler, J., Köhler, A., Leich, N., Misgeld, T., Nöldner, T., Reiher, A., Schartl, M., Seebach?Sproedt, A., Thumberger, T., Schönfelder, G., & Grune, B. (2016). Considerations for a European animal welfare standard to evaluate adverse phenotypes in teleost fish. The EMBO Journal, 35(11), 1151–1154. https://doi.org/10.15252/embj.201694448

Bert, B., Chmielewska, J., Hensel, A., Grune, B., & Schönfelder, G. (2016). The animal experimentation quandary: stuck between legislation and scientific freedom: More research and engagement by scientists is needed to help to improve animal welfare without hampering biomedical research. EMBO Reports, 17(6), 790–792. https://doi.org/10.15252/embr.201642354

Jungnickel, H., Pund, R., Tentschert, J., Reichardt, P., Laux, P., Harbach, H., & Luch, A. (2016). Time-of-flight secondary ion mass spectrometry (ToF-SIMS)-based analysis and imaging of polyethylene microplastics formation during sea surf simulation. The Science of the Total Environment, 563–564, 261–266. https://doi.org/10.1016/j.scitotenv.2016.04.025

Kugler, J., Kemler, R., Luch, A., & Oelgeschläger, M. (2016). Editor’s Highlight: Identification and Characterization of Teratogenic Chemicals Using Embryonic Stem Cells Isolated From a Wnt/β-Catenin-Reporter Transgenic Mouse Line. Toxicological Sciences, 152(2), 382–394. https://doi.org/10.1093/toxsci/kfw094

Kugler, J., Luch, A., & Oelgeschläger, M. (2016). Transgenic Mouse Models Transferred into the Test Tube: New Perspectives for Developmental Toxicity Testing In Vitro? Trends in Pharmacological Sciences, 37(10), 822–830. https://doi.org/10.1016/j.tips.2016.06.009

Raasch, M., Rennert, K., Jahn, T., Gärtner, C., Schönfelder, G., Huber, O., Seiler, A. E. M., & Mosig, A. S. (2016). An integrative microfluidically supported in vitro model of an endothelial barrier combined with cortical spheroids simulates effects of neuroinflammation in neocortex  development. Biomicrofluidics, 10(4), 044102. https://doi.org/10.1063/1.4955184

Schlechtriem, C., Pucher, J., & Michalski, B. (2016). Dietary burden calculations relating to fish metabolism studies. Journal of the Science of Food and Agriculture, 96(5), 1415–1419. https://doi.org/10.1002/jsfa.7607

Weidner, C., Steinfath, M., Opitz, E., Oelgeschläger, M., & Schönfelder, G. (2016). Defining the optimal animal model for translational research using gene set enrichment analysis. EMBO Molecular Medicine, 8(8), 831–838. https://doi.org/10.15252/emmm.201506025

2015:

Chmielewska, J., Bert, B., Grune, B., Hensel, A., & Schönfelder, G. (2015). Der “vernünftige Grund” zur Tötung von überzähligen Tieren. Eine klassische Frage des Tierschutzrechts im Kontext der biomedizinischen Forschung. Natur Und Recht, 37(10), 677–682. https://doi.org/10.1007/s10357-015-2903-9

Riebeling, C., Fischer, K., Luch, A., & Seiler, A. E. M. (2015). Classification of reproductive toxicants with diverse mechanisms in the embryonic stem cell test. The Journal of Toxicological Sciences, 40(6), 809–815. https://doi.org/10.2131/jts.40.809

Schönfelder, G. (2015). Laboratory animals: German initiative opens up animal data. Nature, 519(7541), 33. https://doi.org/10.1038/519033d

Schönfelder, G., Grune, B., & Hensel, A. (2015). Animal welfare: Europe’s first “3Rs” governmental centre. Nature, 527(7576), 38. https://doi.org/10.1038/527038e

Smirnova, L., Seiler, A. E. M., & Luch, A. (2015). microRNA Profiling as Tool for Developmental Neurotoxicity Testing (DNT). Current Protocols in Toxicology, 64, 20.9.1-20.9.22. https://doi.org/10.1002/0471140856.tx2009s64